Cell Signaling Technology Intelligence Profile

cellsignal.comLast reviewed: October 20, 2026Research coverage: 86%

Overall data confidence:Unknown

Identity confidence

High

9 of 10 identity fields independently documented

Corporate continuity

Continuous operation at cellsignal.com since its 1999 registration; site live and current as of 2026-10-20 (2026 promotions and a September/October 2026 company blog).

Based on domain history and corporate record fields

Regulatory exposure

None identified

Derived from published risk flags

Evidence integrity

High

7 of 7 testing fields documented

Transaction transparency

Low

1 of 5 commercial fields documented

Change activity

None tracked

0 change events tracked

Research Incomplete

Research coverage for this vendor is 86%. Our research on Cell Signaling Technology remains incomplete — what we have verified so far is published below, and research is continuing.

Still to research:

Refund policy reviewed (refund_return_policy)
Shipping policy reviewed (shipping_fulfillment_representations)
Payment methods reviewed (accepted_payment_methods)
Public summary reviewed

Overview#

Established, identity-verified U.S. research-reagent manufacturer (Cell Signaling Technology, Inc., Massachusetts; HQ 3 Trask Lane, Danvers, MA) operating continuously since 1999 at cellsignal.com (registered 1999-06-15). FIT: passes the peptide gate with honest scoping — antibodies are the primary business, but CST sells priced peptide products (e.g., Phospho-CREB (Ser133) Blocking Peptide #1090; SignalScan Peptide Mix products with heavy-labeled standard peptides; PTMScan Peptide Purification Kit #35741). Regulatory searches (FDA warning letters/recalls/import alerts, FTC, state AG, courts) returned No Record Found in the defined searches. CST was not among the 15 companies named in the August 2026 Richardson & David antibody-image dataset and publicly pledged zero data reuse. Gaps: Massachusetts registered agent and U.S. payment/returns/shipping/terms documents were not retrieved in this pass (4 policy fields Unknown). No High/Critical severity findings.

Company Identity#

Vendor Brand NameCell Signaling Technology (CST)

HighSource: Cell Signaling Technology homepage

Primary Website Domaincellsignal.com

ModerateSource: Cell Signaling Technology — official website (intake domain confirmation)

Legal Entity NameCell Signaling Technology, Inc.

HighSource: Minnesota Secretary of State business filing — Cell Signaling Technology Inc. (foreign corporation)

State of RegistrationMassachusetts

HighSource: Minnesota Secretary of State business filing — Home Jurisdiction: Massachusetts

Entity StatusActive / In Good Standing (Minnesota foreign-corporation registration, annual renewal filed 11/19/2025; Massachusetts home-jurisdiction status not directly retrieved)

ModerateSource: Minnesota Secretary of State business filing — status and renewal history

Incorporation / Formation Date1999 (founded 1999; exact Massachusetts filing date not retrieved)

ModerateSource: Cell Signaling Technology — company history/About materials (founded 1999)

Named Principals / ManagersMichael J. Comb, PhD — Founder, President & CEO; Roberto Polakiewicz, PhD — Chief Scientific Officer; Matthew Curran — Chief Financial Officer; Benjamin Comb — SVP Corporate Strategy; Craig Thompson — VP Global Operations

ModerateSource: Minnesota Secretary of State filing — Chief Executive Officer: Michael Comb

Registered AgentNot independently verified

UnknownSource: Minnesota Secretary of State filing reviewed for agent information (lists MN foreign-registration agent only)

Operating Address3 Trask Lane, Danvers, MA 01923, USA

HighSource: CST product datasheet header (3 Trask Lane, Danvers, MA 01923)

Address ConsistencyConsistent — 3 Trask Lane, Danvers, MA 01923 appears on CST datasheets, in the Minnesota SoS filing, and in third-party profiles. An earlier Beverly, MA (Cummings Center) address in older materials reflects the pre-2005 headquarters, not a conflicting current address.

HighSource: CST product datasheet header

Domain and Digital Identity#

Domain Registration Date1999-06-15

HighSource: Verisign RDAP record for cellsignal.com

Domain Ownership / Registrar Change HistoryRegistrar: MarkMonitor Inc.; registrant identity redacted in RDAP; domain last changed 2026-05-14; expires 2027-06-15. No evidence of an ownership transfer; the domain has been held continuously since 1999 registration.

ModerateSource: Verisign RDAP record for cellsignal.com

Website ContinuityContinuous operation at cellsignal.com since its 1999 registration; site live and current as of 2026-10-20 (2026 promotions and a September/October 2026 company blog).

ModerateSource: Cell Signaling Technology homepage (current 2026 content)

Contact Channel IntegrityTechnical support +1-877-678-8324 published on cellsignal.com product pages; ordering and support channels presented consistently across the corporate site, datasheets, and blog.cellsignal.com.

HighSource: CST product page footer — 'Technical Support Call: +1-877-678-8324'

Regulatory and Legal History#

FDA Warning Letter HistoryNo Record Found in the defined search

HighSource: Defined web search of FDA warning letters — no letter naming Cell Signaling Technology

FDA Recall / Safety Action HistoryNo Record Found in the defined search

HighSource: Defined web search of FDA recalls — no action naming Cell Signaling Technology

FDA Import Alert / Detention ExposureNo Record Found in the defined search

HighSource: Defined web search of FDA import alerts — no alert naming Cell Signaling Technology

FTC Enforcement HistoryNo Record Found in the defined search

HighSource: Defined web search of FTC enforcement — no action naming Cell Signaling Technology

State Regulatory / Attorney General ActionsNo Record Found in the defined search

ModerateSource: Defined web search of state AG/regulatory actions — none naming Cell Signaling Technology

Relevant Civil LitigationNo Record Found in the defined search

ModerateSource: Defined web search of court records/news — no material litigation naming Cell Signaling Technology

Criminal / Injunctive ProceedingsNo Record Found in the defined search

ModerateSource: Defined web search of DOJ/court actions — none naming Cell Signaling Technology

Testing and COA Evidence#

Public COA AvailabilityCST publicly posts detailed product datasheets with application validation data for each catalog product; formal lot-specific Certificates of Analysis are not the primary public documentation model for its antibody catalog. Peptide products (e.g., blocking peptides, SignalScan peptide mixes) are documented on product pages/datasheets in the same way.

ModerateSource: CST product datasheet (publicly posted validation data)

Batch / Lot SpecificityPartial — datasheets are catalog-product-specific and present validation results for the tested material; per-lot certificates for each production lot are not routinely published.

ModerateSource: CST product datasheet

Independent Laboratory IdentityNo independent third-party testing laboratory program identified — product validation is performed in-house by CST, which its public statements emphasize (in-house, application-specific testing).

ModerateSource: CST blog — 'An Open Letter Concerning Antibody Data Integrity' (in-house testing position)

COA Verification StatusNo public CoA verification portal identified in the defined search; product documentation is verified by reference to the datasheets published on cellsignal.com.

ModerateSource: Cell Signaling Technology website (no CoA lookup tool identified)

Test RecencyValidation data on current product pages is actively maintained (site content current to October 2026); per-product re-test dates are not published.

LowSource: Cell Signaling Technology homepage/catalog (current 2026)

Testing CoverageIn-house validation across applications (western blot, IHC, immunofluorescence, flow cytometry, ELISA) documented per product on datasheets; peptide products include quantified standards (e.g., SignalScan Peptide Mix peptides quantified by amino acid analysis).

ModerateSource: CST product pages/datasheets (application validation data)

Evidence ConsistencyNotable: CST was NOT among the 15 companies named in the August 2026 Richardson & David vendor antibody-image dataset (per C&EN's published list of the 15). CST's CSO published an open letter in response to that industry report pledging zero data reuse and no image cloning in CST materials.

ModerateSource: C&EN — 'New report suggests widespread image manipulation in antibody market' (Aug 2026), listing the 15 companies

Payment, Refund and Shipping#

Accepted Payment MethodsNot independently verified

UnknownSource: Cell Signaling Technology website (priced catalog; payment methods not stated on retrieved pages)

Refund / Return PolicyNot independently verified

UnknownSource: Cell Signaling Technology website (U.S. returns policy not retrieved)

Shipping & Fulfillment RepresentationsNot independently verified

UnknownSource: Cell Signaling Technology website (U.S. shipping terms not retrieved)

Terms / Policy StabilityNot independently verified

UnknownSource: Cell Signaling Technology website (U.S. terms of sale not retrieved)

Customer Complaint PatternNo Record Found in the defined search — no pattern of customer complaints identified in the web/BBB searches performed.

ModerateSource: Defined web complaint search — no complaint pattern naming Cell Signaling Technology

Material Changes#

No material changes recorded.

Sources#

Minnesota Secretary of State business filing — Cell Signaling Technology Inc. (foreign corporation)Tier 1 · AuthoritativeSos Business SearchAuthoritative

Retrieved: October 20, 2026